Cinnamic acids and derivatives
Apexbio Technology LLC Entacapone 130929-57-6 10mM (in 1mL DMSO)
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
TARGETMOL CHEMICALS INC ENTACAPONE 100MG
Also available in 5 mg 10 mg 25 mg 50 mg 200 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). purity: 99%
Cayman Chemical Plnt TurmerIc CurcumIn 5g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Apexbio Technology LLC Entacapone sodium salt 1047659-02-8 100mg
Entacapone sodium salt (CAS 1047659-02-8) is a nitrocatechol small molecule that acts as a selective and reversible inhibitor of catechol-O-methyltransferase (COMT) a Mg2 -dependent enzyme involved in the metabolism of catecholamines and related compounds In biochemical assays entacapone exhibits an IC50 of 20 1 nM and a Ki of 10 7 nM for COMT inhibition The presence of a nitro group ortho to the hydroxyl group in its structure contributes to its inhibitory potency Entacapone has been widely used in research focused on Parkinson s disease particularly to study the modulation of levodopa bioavailability and pharmacokinetics
Apexbio Technology LLC Tyrphostin A1 2826-26-8 50mg
Tyrphostin A1 (CAS 2826-26-8) is a small molecule inhibitor targeting tyrosine kinase activity specifically involved in disrupting intracellular signaling pathways in immune cells It has been shown to interfere with CD40 ligand-induced signaling resulting in suppressed interleukin-12 (IL-12) secretion by macrophages and reduced differentiation of antigen-induced T helper 1 (Th1) cells Tyrphostin A1 is widely utilized in studies investigating cell-to-cell signaling immune response modulation and the mechanisms underlying inflammatory processes particularly in the context of autoimmune disease models
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | 99.2% | 305.29 g/mol | C14H15N3O5 | 5 MG
Entacapone (Standard) is an analytical reference standard of entacapone provided for research and analytical use. Supplied in small quantitative sizes suitable for assay development, method validation, and quality control, the product includes batch documentation and a Certificate of Analysis reporting high purity. It is used as a reference material in studies involving COMT inhibition and related biochemical assays.
- Analytical standard for assay development and method validation.
- Available in small sizes, including a 5 mg vial.
- Certified purity approximately 99.2% (COA available).
- Useful for quality control and reference material applications.
- Molecular formula C14H15N3O5; molecular weight 305.29 g/mol.
TARGETMOL CHEMICALS INC I-OME-TYRPHOSTIN AG 538 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4K(alpha) (IC50 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-deficient PANC1 cells. purity: 96%
TARGETMOL CHEMICALS INC POLYINOSINIC-POLYCYTIDYL 25MG
Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Polyinosinic-polycytidylic acid (Poly(IC)) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-like receptor- 3 (TLR3) agonist. purity: 98%
Med Vet International Fluoxetine Capsules (Prozac), 20mg, 100ct
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Fluoxetine is a generic form of PROZac and is an SSRI antidepressant. It affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive disorder.
Med Vet International Fluoxetine, 20mg, 30 Tablets
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Fluoxetine is a generic form of PROZac and is an SSRI antidepressant. It affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive disorder.
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | 99.2% | C14H15N3O5 | 10MG
Entacapone (Standard) is an analytical reference standard of entacapone (CAS 130929-57-6) supplied for research and analytical applications. It is intended for use in qualitative and quantitative assays, method development, and validation for chromatographic and mass spectrometric techniques.
- Provides a certified analytical standard for assay development and method validation.
- High purity reference material (≈99.2%).
- Suitable for HPLC, GC, and MS applications.
- Light yellow solid, stable under recommended storage conditions.
- Supports studies of catechol-O-methyltransferase activity and Parkinson's disease research.
Sigma Aldrich Fine Chemicals Biosciences Rivaroxaban R enantiomer U20MG
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Medchemexpress LLC SAR405 R enantiomer | 1946010-79-2 | 99.9% | 443.85 | C19H21ClF3N5O2 | 10MG
SAR405 R enantiomer is the less active stereoisomer of the PIK3C3/Vps34 inhibitor SAR405, provided as a solid for in vitro research use only. It is suited for comparative pharmacology and control studies and includes handling and storage guidance for reliable experimental use.
- Less active enantiomer used as a comparative control in assays.
- High purity (≈99.9%).
- Solid, white to off-white appearance.
- Molecular formula C19H21ClF3N5O2; molecular weight 443.85.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store powder at -20°C for long-term stability; store solutions at -80°C.
- Intended for laboratory research use only.