Cinnamic acids and derivatives
Medchemexpress LLC 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 100.0% | 238.24 | 50 G
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of *Polygala tenuifolia WILLD*. It has an anti-stress effect and prolongs sleeping time in animals. It increases the expression of GAD65 and the γ-subunit of the GABAA receptor, with no effect on the α- or β-subunits.
- Isolated from the roots of *Polygala tenuifolia WILLD*.
- Exhibits anti-stress effects.
- Prolongs sleeping time in animals.
- Increases expression of GAD65 and γ-subunit of GABAA receptor.
Medchemexpress LLC 3,4,5-Trimethoxycinnamic acid | 90-50-6 | 99.96% | 238.24 | 1 ML
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of *Polygala tenuifolia WILLD*. It exhibits an anti-stress effect and prolongs sleeping time in animals. This compound increases the expression of GAD65 and the γ-subunit of the GABAA receptor, but does not affect the amounts of α- or β-subunits. It is for research use only.
- Anti-stress effect
- Prolongs sleeping time in animals
- Increases expression of GAD65 and γ-subunit of GABAA receptor
- For research use only
Medchemexpress LLC Ferulic acid 4-O-sulfate | 86321-29-1 | 98.07% | 274.25 | 100 MG
Ferulic acid 4-O-sulfate, also known as Ferulic acid 4-sulfate, is a metabolite of Ferulic acid that has been observed to relax arteries and decrease blood pressure in mice.
- In vitro: This compound, at concentrations ranging from 0.1 to 30 μM, elicited significant concentration-dependent relaxations in the aorta, femoral, and saphenous arteries of mice.
- In vivo: When administered intravenously to male Swiss mice at dosages of 16.13 and 161.3 μg/kg, ferulic acid 4-O-sulfate demonstrated the ability to relax arteries and lower blood pressure, with a significant decrease in mean arterial pressure (MAP) observed immediately post-injection.
Apexbio Technology LLC Entacapone 130929-57-6 100mg
Entacapone (CAS 130929-57-6) is a selective second-generation inhibitor of catechol-O-methyltransferase (COMT) It demonstrates potent inhibition of total COMT in mouse liver with reported IC50 and Ki values of 20 1 nM and 10 7 nM respectively In rat models IC50 values for soluble COMT and membrane-bound COMT are 14 3 nM and 73 3 nM Entacapone is primarily utilized in research as an adjunct to levodopa and dopa decarboxylase inhibitor regimens in Parkinson s disease studies given its ability to suppress the formation of 3-O-methyldopa thereby enhancing levodopa bioavailability and prolonging its pharmacological effect
Medchemexpress LLC M-coumaric acid (standard) | 588-30-7 | 99.9% | 164.16 | 10 MG
M-coumaric acid (standard) | 588-30-7 | 99.9% | 164.16 | 10 MG
Apexbio Technology LLC Cinnamic acid 621-82-9 100mg
Cinnamic acid (CAS 621-82-9) is an aromatic unsaturated carboxylic acid naturally occurring in various plants particularly in cinnamon and vanilla It exhibits a range of bioactivities including antimicrobial anti-inflammatory and antioxidant effects Mechanistically cinnamic acid has been shown to modulate inflammatory pathways and oxidative stress responses thereby influencing cellular signaling cascades associated with disease progression Owing to these properties it is investigated in biomedical research for its potential in cancer intervention as well as for broader applications in pharmacological studies of inflammation and infection
Cayman Chemical Plnt TurmerIc CurcumIn 5g
A yellow pigment with diverse biological activities; inhibits NO production (IC50 = 6 μM) and reduces iNOS activity in LPS-stimulated RAW 264.7 cells; inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells; decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis; prevents ovalbumin-induced accumulation of 3-NT in mouse heart; reduces TPA-induced tumor formation in mouse skin (1-10 μmol); reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-NQO in rats
Medchemexpress LLC Tyrphostin AG30 | 122520-79-0 | MFCD09739079 | 99.7% | 205.17 | C10H7NO4 | 1 ML
Tyrphostin AG30 (CAS 122520-79-0) is a small-molecule inhibitor of EGFR tyrosine kinase supplied as a 10 mM solution in DMSO (1 mL), intended for biochemical and cell-based research.
- Potent and selective EGFR tyrosine kinase inhibition.
- Supplied as a ready-to-use 10 mM solution in DMSO.
- High purity suitable for research applications.
- Molecular weight 205.17 and formula C10H7NO4 provided for characterization.
- Storage recommendations provided to maintain compound stability.
Chem-Impex International, Inc. trans-Ferulic acid | 1135-24-6 | MFCD00004400 | 25G
trans-Ferulic acid, 1135-24-6, MFCD00004400, 25G
eMolecules 2-(3'-Fluorobenzyloxy)phenylboronic acid | 871126-24-8 | 1G | Purity: 98%
Combi-Blocks | 2-(3'-Fluorobenzyloxy)phenylboronic acid | 1G | 871126-24-8 | MFCD07784392
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Medchemexpress LLC 2-Hydroxycinnamic acid | 614-60-8 | CB1140462 | 99.9% | 164.16 | 5 G
2-Hydroxycinnamic acid is a phenolic acid possessing antimicrobial and antioxidant properties. It exhibits antimicrobial activity against Staphylococcus aureus and has shown to not be susceptible to drug resistance. Additionally, 2-Hydroxycinnamic acid demonstrates inhibitory effects on the infection of HIV/SARS-CoV S pseudovirus, with an IC50 of 0.3 mM. It also has neuroprotective and antitumor activities.
- Possesses antimicrobial properties.
- Has antioxidant properties.
- Exhibits antimicrobial activity against Staphylococcus aureus.
- Not susceptible to drug resistance.
- Demonstrates inhibitory effects on the infection of HIV/SARS-CoV S pseudovirus.
- Has neuroprotective activities.
- Has antitumor activities.